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Feb 8, 2021 · Esketamine nasal spray was authorised by the European Commission for use in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor (SNRI) in adult patients with treatment-resistant major depressive disorder (TRD) in December 2019 SPRAVATO® (esketamine) is a prescription nasal spray for treatment-resistant depression See full Prescribing & Safety Info, including BOXED WARNINGS The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that the European Commission (EC) has authorised the expanded use of SPRAVATO ® (esketamine nasal spray), co-administered with oral antidepressant therapy in adults with a moderate to severe episode of MDD, as acute short term treatment, for the rapid reduction of depressive symptoms, which according to clinical Dec 20, 2019 · Esketamine nasal spray—sold under the name Spravato—has been approved by the European Commission (EC) in combination with a selective serotonin reuptake inhibitor or serotonin and norepinephrine reuptake inhibitor, for adults living with treatment resistant major depressive disorder 1 The spray, sold by Janssen (the pharmaceutical branch of Johnson and Johnson), will be made available for Feb 8, 2021 · Esketamine nasal spray was authorised by the European Commission for use in combination with a selective serotonin reuptake inhibitor (SSRI) or serotonin and norepinephrine reuptake inhibitor EMEA Innovative Medicine SPRAVATO® (Esketamin SPRAVATO® (Esketamine Nasal Spray) Authorised in Europe for the Rapid Reduction of Depressive Symptoms in a Psychiatric Emergency for Patients with Major Depressive DisorderSPRAVATO® (Esketamine) Nasal Spray Approved in Europe for Adults with Treatment-Resistant Major Depressive Disorder Esketamine nasal spray offers the first new mechanism of action for an antidepressant in 30 years EC approval is based on data from a clinical trial programme in adult patients with treatment-resistant major depressive disorder, including five Phase 3 trials Treatment with